SOLACE2 has achieved complete accrual, thanks to the 114 women across Australia who have generously participated, and the Investigators and staff at 15 sites in QLD, NSW, VIC, TAS and SA dedicated to the trial.
SOLACE2 is a 3-arm randomised, open label, multi-centre, Phase II trial of olaparib and durvalumab in platinum-sensitive, high grade serous ovarian cancer.
ANZGOG Chair and SOLACE 2 Principal Investigator, Prof Clare Scott AM.
Led by ANZGOG in collaboration with the NHMRC Clinical Trials Centre (CTC), the University of Sydney, the Walter and Eliza Hall Institute of Medical Research and RMIT University, SOLACE2 is an important ovarian cancer trial which offers an opportunity for women with the most common type of ovarian cancer (high grade serous) to receive immunotherapy and PARP inhibitor treatment at the first sign of relapse, when they’re likely to derive most benefit. SOLACE2 is investigating whether immunological priming could improve the subsequent response to immunotherapy for these women.
SOLACE2 has a strong translational focus, led by world-class laboratory researchers. Translational research describes the process where scientific discoveries in the laboratory translate into improved practice in the clinic. Prof Clare Scott AM and Prof Magdalena Plebanski, and their teams at WEHI and RMIT respectively, have overcome the challenges of recent years to continue to optimally process precious patient samples.
Prof Clare Scott AM emphasised the value of these samples:
“These bloods are the total life force for determining why some people respond better than others and whether we can improve the immune attack on the cancer for those who respond less well.“
The trial data will be analysed, and patient samples tested to address the translational study aims, including identification of immune or genomic biomarkers that are prognostic and/or predictive of response to treatment, and the development of potential vaccine-based treatment strategies.
We thank all participating women and their families, and participating sites, for their long-term commitment to the study.
